Autopilot is best for planning road trips within the United States and Canada. Your destination could be a couple weeks in Vancouver, BC, a day trip to the Grand Canyon, a weekend in Boston, MA, or anywhere in between!
Autopilot is focused on road trips, it doesn't incorporate flights or other modes of transportation. If you're flying somewhere before starting the road travel portion of your trip, you should set the location you're flying to as the starting point for your Autopilot trip.